Our lab is located in Department of Human Genetics at University of Chicago.  We are interested in understanding the genetic basis of complex human diseases. What are the genetic variants that influence the susceptibility of diseases? What are the mechanisms linking genetic changes to phenotypic consequences? Human diseases are often characterized by disruption of regulatory process. We are broadly interested in how the regulatory sequences in the genomes interact with cellular environments to determine gene expression. We develop and employ computational and statistical tools to address these challenges.

At University of Chicago, we are fortunate to be in a very stimulating and supportive environment. We share our space with the computational labs of Matthew Stephens and John Novembre. We interact regularly with other groups in our department that share our interests in human disease genetics, regulatory genomics and evolution. We also have collaborations with other outstanding researchers in the university and affiliated hospitals, including Section of Genetic Medicine, Chuan He lab, and Duan lab at Northshore Hospital .

One main mission of our lab is to train next generation of scientists. Students and postdocs at the lab will have opportunities to learn both quantitative skills and the ability to use such skills to attack important biological problems. We believe there is a great demand of people with such training in both academia and industry, and we will create an environment that is conducive to learning and applying new skills. If you are interested in joining the lab, read this page!