Xin He

Principal Investigator

Xin completed his PhD in Computer Science in 2009 at University of Illinois at Urbana-Champaign, where he worked with Saurabh Sinha. Before his current position, Xin completed postdoc training with Dr. Hao Li at Department of Biochemistry of UCSF, and with Drs. Kathryn Roeder and Ziv Bar-Joseph at Lane Center for Computational Biology of Carnegie Mellon University. Xin is interested in statistical genetics and genomics, computational biology/bioinformatics and evolutionary genomics.



Wesley Crouse


Wes received his Ph.D. in Bioinformatics and Computational Biology in 2019 from the University of North Carolina at Chapel Hill, advised by William Valdar and Samir Kelada. His dissertation research focused on Bayesian nonparametric approaches for genetic association. Wes joined the lab in Feb, 2021 and is jointly supervised by Dr. Matthew Stephens. He is interested in developing statistical methods for causal inference in biomedicine.


Kevin Luo


Kevin (Kaixuan罗凯旋) Luo completed his PhD in Computational Biology and Bioinformatics in 2016 from Duke University, where he was supervised by Dr. Alex Hartemink, and collaborated with Greg Crawford, David MacAlpine, and Li Ma. His PhD research focused on modeling the dynamics of genome-wide transcription factor and nucleosome occupancy. Kevin joined the lab in October, 2016. He is jointly supervised by Dr. Matthew Stephens, and in close collaboration with Dr. Chuan He. Kevin is interested in developing statistical and machine learning methods to better understand the mechanisms by which genetic variation impacts gene regulation.


Siming Zhao


Siming Zhao receieved her Ph.D. in 2015 in Genetics from Yale University advised by Dr. Richard Lifton. Siming joined the lab in Oct, 2015 and is co-supervised by Dr. Matthew Stephens. She is interested in cancer genomics and applying statistical methods to understand the genetic basis of human diseases.



Alan Selewa

PhD student

Alan received his BS in Physics from the University of Illinois in Urbana-Champaign and joined the PhD program in Biophysical Sciences at the University of Chicago in 2016. He joined the lab in September, 2017 and is jointly supervised by Dr. Oni Basu. He is interested in developing statistical methods for analyzing single-cell ‘omics data in order to study cell-to-cell variability and its role in human disease.


Yifan Zhou

PhD student

Yifan Zhou (周逸凡) obtained her BS in Chemistry and Biology from Tsinghua University in China and joined the PhD program in Biophysical Sciences at University of Chicago in 2016. She joined the lab in August, 2017 and is jointly supervised by Dr. Mengjie Chen. Yifan is interested in using statistical methods on large scale gene datasets to better understand the architecture and mechanisms of gene regulation, as well as to identify disease related non-coding elements.



Jing Gu

PhD student

Jing received her BS and MS in Biochemistry from UC San Diego, and started the PhD program in Genetics, Genomics and System Biology at the University of Chicago in 2019.
She joined the lab in September, 2020. She is interested in using statistical methods to integrate molecular traits and genetic associations to better understand complex disease etiology.


Ben Lai

PhD student

Ben (Boqiao) received his BS in Computer Science from Columbia University and BA in liberal arts study from Bard College. He joined the PhD program at Toyota Technological Institute at Chicago (TTIC) in 2018 and joined the lab in September 2020, jointly supervised by Dr. Jinbo Xu. He is interested in developing interpretable machine learning and statistical models to study biological sequences in various contexts.


Sheng Qian

Rotation student

Sheng Qian obtained his BS in Biometry & Statistics from Cornell University and in Applied Bioscience from Zhejiang University jointly in 2019. He joined the lab in July, 2019 as a research assistant, and then joined Human Genetics PhD program in 2020. He is now a rotation student in the lab. He is interested in the development and application of machine learning approaches in precision medicine.


Xiaolong Sun

Visiting student

Xiaotong Sun (孙晓彤) is a visiting PhD student from Peking University in China. She obtained her BS in Statistics from Shandong University. Xiaotong joint the lab in September, 2019. She is interested in understanding genetic regulation mechanisms of human diseases employing statistic methods.


Christie Du

Undergraduate student

Christie Du is a 4th year University of Chicago undergraduate majoring in Biology and minoring in Computer Science. She joined the lab in June 2020 as a research assistant. She is interested in applying statistical methods to better understand the mechanisms of human disease and to identify disease risk alleles.



Nicholas Knoblauch

PhD student

Nick was a PhD student of the Genetics, Genomics and Systems Biology (GGSB) program at U of Chicago from 2014 to 2020. His PhD work focused on developing and applying statistical methods to understand genetics of complex traits, particularly pre-term birth. Nick currently works at Genentech.


Min Qiao

Visiting student

Min was a visiting PhD student from UTHealth at Houston. She worked in the lab from 2016 to 2020. Her work included statistical fine-mapping in genomewide association studies and analysis of copy number variants. She is now a staff scientist at Columbia University.


Jean Morrison


Jean Morrison joined the lab in Oct, 2016 and was co-supervised by Dr. Matthew Stephens. Her work focused on methods for analyzing genetic data of multiple traits, including Mendelian Randomization. Jean is now a tenure-track Assistant Professor at Department of Biostatistics and University of Michigan, Ann Arbor.


Yuwen Liu


Yuwen (刘毓文)  was a postdoc in the lab from July, 2015 to Jul, 2018. He is now a PI at Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences.


Shengtong Han


Shengtong Han was a postdoc in the lab from Apr, 2015 to Aug, 2018. He is now a  Visiting Assistant Professor in Biostatistics in Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee.

Yanyu Liang

Research assistant

Yanyu Liang was a Research Assistant in the lab from 2016 to 2017. She did a rotation in the lab in the spring of 2018. She is now a student at Genomics and Systems Biology (GGSB) program, working in the lab of Haky Im.


Zhongshan Li

Visiting scholar

Zhongshan Li (李中山) visited the lab from Sep. 2017 - Sep. 2019 as a visiting scholar. He now works at the Institute of Genomic Medicine, Wenzhou Medical University. Zhongshan’s research focus on identification of pathogenic genetic mutations for human neuropsychiatric disorders using bioinformatics and statistics methods.


Yubin Xie 

Research Assistant

Yubin Xie was a research assistant in the lab from October, 2016 to June, 2017. He is now a PhD student at Tri-Institutional PhD Program in Computational Biology & Medicine.


Tiffany Ke

Visiting student

Tiffany, Xinxin KE (柯欣欣) was a visiting student from School of Life Sciences, The Chinese University of Hong Kong. She visited the lab from Oct, 2017 to Mar, 2018.